SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. SYPRINE® is not recommended to treat cystinuria (a condition where a protein known as cystine is excreted into the urine), rheumatoid arthritis, or a disease affecting the bile ducts in the liver known as biliary cirrhosis.
IMPORTANT SAFETY INFORMATION
- Do not take SYPRINE® if you are allergic to it or any parts of the formulation.
- You should remain under regular medical supervision the entire time you are taking SYPRINE®. Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women.
- Take SYPRINE® on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
- Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
- The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.
- Do not take mineral supplements because they may block the absorption of SYPRINE®.
You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch
or call 1-800-FDA-1088.
Please click here for full Prescribing Information for SYPRINE® Capsules.