The Wilson Disease Association offers patients a tool for tracking the copper and zinc content in their body from each visit with the healthcare professional. The Lab Tracker and Copper Calculator is available for online use or can be downloaded as a Microsoft® Excel spreadsheet that will automatically calculate copper levels, based on the information entered, or as a blank PDF that lets the patient enter the data by hand. The results of the lab tracker and copper calculator can help you, the healthcare professional, monitor the patients' copper levels.1
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Syprine® (trientine hydrochloride) is indicated in the treatment of patients with Wilson’s disease who are intolerant of penicillamine. Clinical experience with Syprine is limited and alternate dosing regimens have not been well-characterized; all endpoints in determining an individual patient’s dose have not been well defined. Syprine and penicillamine cannot be considered interchangeable. Syprine should be used when continued treatment with penicillamine is no longer possible because of intolerable or life endangering side effects.
Unlike penicillamine, Syprine is not recommended in cystinuria or rheumatoid arthritis. The absence of a sulfhydryl moiety renders it incapable of binding cystine and, therefore, it is of no use in cystinuria. In 15 patients with rheumatoid arthritis, Syprine was reported not to be effective in improving any clinical or biochemical parameter after 12 weeks of treatment.
Syprine is not indicated for treatment of biliary cirrhosis.